USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P06730 USC-OGP 2-DE database:  P06730 P06730 General information about the entry View entry in simple text format Entry name IF4E_HUMAN Primary accession number P06730 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Eukaryotic translation initiation factor 4E; Short=eIF-4E; Short=eIF4E; AltName: Full=eIF-4F 25 kDa subunit; AltName: Full=mRNA cap-binding protein;. Gene name Name=EIF4E Synonyms=EIF4EL1, EIF4F Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0806: pI=5.31; Mw=26139 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1273: pI=5.83; Mw=27756 Cross-references UniProtKB/Swiss-Prot P06730; IF4E_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name IF4E_HUMAN Primary accession number P06730 Secondary accession number(s) B7Z6V1 D6RCQ6 Q96E95 Sequence was last modified on  February 1, 1996 (version 2) Annotations were last modified on  March 15, 2017 (version 195) Name and origin of the protein Description RecName: Full=Eukaryotic translation initiation factor 4E; Short=eIF-4E; Short=eIF4E; AltName: Full=eIF-4F 25 kDa subunit; AltName: Full=mRNA cap-binding protein; Gene name Name=EIF4E Synonyms=EIF4EL1, EIF4F Encoded on Name=EIF4E; Synonyms=EIF4EL1, EIF4F Keywords 3D-structure; Acetylation; Alternative splicing; Autism; Autism spectrum disorder; Chromosomal rearrangement; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; RNA-binding; Translation regulation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M15353; AAC13647.1; -; mRNA EMBL AK300982; BAH13387.1; -; mRNA EMBL AC019131; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC093836; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC012611; AAH12611.1; -; mRNA EMBL BC035166; AAH35166.1; -; mRNA EMBL BC043226; AAH43226.1; -; mRNA EMBL BM849222; -; NOT_ANNOTATED_CDS; mRNA CCDS CCDS34031.1; -. [P06730-1]; . CCDS CCDS47109.1; -. [P06730-3]; . CCDS CCDS54779.1; -. [P06730-2]; . PIR A26411; A26411; . RefSeq NP_001124150.1; NM_001130678.2. [P06730-3]; . RefSeq NP_001124151.1; NM_001130679.2. [P06730-2]; . RefSeq NP_001317946.1; NM_001331017.1; . RefSeq NP_001959.1; NM_001968.4. [P06730-1]; . UniGene Hs.13211; -; . UniGene Hs.249718; -; . PDB 1IPB; X-ray; 2.00 A; A=1-217 PDB 1IPC; X-ray; 2.00 A; A=1-217 PDB 1WKW; X-ray; 2.10 A; A=27-217 PDB 2GPQ; NMR; -; A=1-217 PDB 2V8W; X-ray; 2.30 A; A/E=1-217 PDB 2V8X; X-ray; 2.30 A; A/E=1-217 PDB 2V8Y; X-ray; 2.10 A; A/E=1-217 PDB 2W97; X-ray; 2.29 A; A/B=1-217 PDB 3AM7; X-ray; 2.20 A; A=27-217 PDB 3TF2; X-ray; 2.10 A; A/B/C/D=1-217 PDB 3U7X; X-ray; 2.10 A; A/B=1-217 PDB 4AZA; X-ray; 2.16 A; A/C=1-217 PDB 4BEA; X-ray; 2.57 A; A=1-217 PDB 4DT6; X-ray; 2.60 A; A=1-217 PDB 4DUM; X-ray; 2.95 A; A=1-217 PDB 4TPW; X-ray; 1.50 A; A/B=28-217 PDB 4TQB; X-ray; 1.59 A; A/B=28-217 PDB 4TQC; X-ray; 1.80 A; A/B=28-217 PDB 4UED; X-ray; 1.75 A; A=36-217 PDB 5EHC; X-ray; 2.40 A; A=1-217 PDB 5EI3; X-ray; 1.71 A; A=1-217 PDB 5EIR; X-ray; 2.69 A; A=1-217 PDB 5EKV; X-ray; 3.61 A; A/C=1-217 PDB 5GW6; X-ray; 1.97 A; A=23-217 PDB 5T46; X-ray; 1.53 A; A/C=1-217 PDBsum 1IPB; -; . PDBsum 1IPC; -; . PDBsum 1WKW; -; . PDBsum 2GPQ; -; . PDBsum 2V8W; -; . PDBsum 2V8X; -; . PDBsum 2V8Y; -; . PDBsum 2W97; -; . PDBsum 3AM7; -; . PDBsum 3TF2; -; . PDBsum 3U7X; -; . PDBsum 4AZA; -; . PDBsum 4BEA; -; . PDBsum 4DT6; -; . PDBsum 4DUM; -; . PDBsum 4TPW; -; . PDBsum 4TQB; -; . PDBsum 4TQC; -; . PDBsum 4UED; -; . PDBsum 5EHC; -; . PDBsum 5EI3; -; . PDBsum 5EIR; -; . PDBsum 5EKV; -; . PDBsum 5GW6; -; . PDBsum 5T46; -; . ProteinModelPortal P06730; -; . SMR P06730; -; . BioGrid 108292; 50; . DIP DIP-22N; -; . IntAct P06730; 35; . MINT MINT-85626; -; . BindingDB P06730; -; . ChEMBL CHEMBL4848; -; . DrugBank DB01649; 7-Methyl-Gpppa; . DrugBank DB02716; 7-Methyl-Guanosine-5'-Triphosphate; . DrugBank DB01960; 7n-Methyl-8-Hydroguanosine-5'-Diphosphate; . DrugBank DB05165; LY2275796; . iPTMnet P06730; -; . PhosphoSitePlus P06730; -; . SwissPalm P06730; -; . BioMuta EIF4E; -; . DMDM 1352435; -; . OGP P06730; -; . REPRODUCTION-2DPAGE IPI00027485; -; . EPD P06730; -; . MaxQB P06730; -; . PeptideAtlas P06730; -; . PRIDE P06730; -; . TopDownProteomics P06730-1; -. [P06730-1]; . DNASU 1977; -; . Ensembl ENST00000280892; ENSP00000280892; ENSG00000151247. [P06730-3]; . Ensembl ENST00000450253; ENSP00000389624; ENSG00000151247. [P06730-1]; . Ensembl ENST00000505992; ENSP00000425561; ENSG00000151247. [P06730-2]; . GeneID 1977; -; . KEGG hsa:1977; -; . UCSC uc003hue.3; human. [P06730-1]; . CTD 1977; -; . DisGeNET 1977; -; . GeneCards EIF4E; -; . H-InvDB HIX0039231; -; . HGNC HGNC:3287; EIF4E; . HPA CAB004077; -; . HPA CAB016316; -; . HPA HPA051311; -; . MalaCards EIF4E; -; . MIM 133440; gene; . MIM 615091; phenotype; . neXtProt NX_P06730; -; . OpenTargets ENSG00000151247; -; . Orphanet 106; Autism; . PharmGKB PA27714; -; . GeneTree ENSGT00520000055549; -; . HOGENOM HOG000186751; -; . HOVERGEN HBG006130; -; . InParanoid P06730; -; . KO K03259; -; . OMA WTLWYYE; -; . OrthoDB EOG091G0IVA; -; . PhylomeDB P06730; -; . TreeFam TF101526; -; . Reactome R-HSA-1169408; ISG15 antiviral mechanism; . Reactome R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression; . Reactome R-HSA-159227; Transport of the SLBP independent Mature mRNA; . Reactome R-HSA-159230; Transport of the SLBP Dependant Mature mRNA; . Reactome R-HSA-159231; Transport of Mature mRNA Derived from an Intronless Transcript; . Reactome R-HSA-166208; mTORC1-mediated signalling; . Reactome R-HSA-429947; Deadenylation of mRNA; . Reactome R-HSA-72649; Translation initiation complex formation; . Reactome R-HSA-72662; Activation of the mRNA upon binding of the cap-binding complex and eIFs; and subsequent binding to 43S; . Reactome R-HSA-72702; Ribosomal scanning and start codon recognition; . Reactome R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit; . SignaLink P06730; -; . SIGNOR P06730; -; . ChiTaRS EIF4E; human; . EvolutionaryTrace P06730; -; . GeneWiki EIF4E; -; . GenomeRNAi 1977; -; . PRO PR:P06730; -; . Proteomes UP000005640; Chromosome 4; . Bgee ENSG00000151247; -; . CleanEx HS_EIF4E; -; . ExpressionAtlas P06730; baseline and differential; . Genevisible P06730; HS; . GO GO:0033391; C:chromatoid body; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IDA:AgBase; . GO GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0016281; C:eukaryotic translation initiation factor 4F complex; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005845; C:mRNA cap binding complex; IDA:UniProtKB; . GO GO:0000932; C:P-body; IDA:HPA; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:AgBase; . GO GO:0016442; C:RISC complex; IDA:MGI; . GO GO:0019899; F:enzyme binding; IDA:AgBase; . GO GO:0031370; F:eukaryotic initiation factor 4G binding; IDA:AgBase; . GO GO:0070491; F:repressing transcription factor binding; IDA:AgBase; . GO GO:0000340; F:RNA 7-methylguanosine cap binding; IDA:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0000339; F:RNA cap binding; TAS:ProtInc; . GO GO:0003743; F:translation initiation factor activity; IDA:UniProtKB; . GO GO:0001662; P:behavioral fear response; IEA:Ensembl; . GO GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Ensembl; . GO GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:UniProtKB; . GO GO:0030324; P:lung development; IEA:Ensembl; . GO GO:0006406; P:mRNA export from nucleus; TAS:Reactome; . GO GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl; . GO GO:0017148; P:negative regulation of translation; IEA:Ensembl; . GO GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome; . GO GO:0045931; P:positive regulation of mitotic cell cycle; IMP:UniProtKB; . GO GO:0006417; P:regulation of translation; IDA:UniProtKB; . GO GO:0006405; P:RNA export from nucleus; TAS:Reactome; . GO GO:0019827; P:stem cell population maintenance; IEA:Ensembl; . GO GO:0006413; P:translational initiation; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 3.30.760.10; -; 1; . InterPro IPR023398; TIF_eIF4e-like; . InterPro IPR001040; TIF_eIF_4E; . InterPro IPR019770; TIF_eIF_4E_CS; . PANTHER PTHR11960; PTHR11960; 1; . Pfam PF01652; IF4E; 1; . SUPFAM SSF55418; SSF55418; 1; . PROSITE PS00813; IF4E; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]